Intermediate: cognitive phenotypes in bipolar disorder.
نویسندگان
چکیده
BACKGROUND Intermediate cognitive phenotypes (ICPs) are measurable and quantifiable states that may be objectively assessed in a standardized method, and can be integrated into association studies, including genetic, biochemical, clinical, and imaging based correlates. The present study used neuropsychological measures as ICPs, with factor scores in executive functioning, attention, memory, fine motor function, and emotion processing, similar to prior work in schizophrenia. METHODS Healthy control subjects (HC, n=34) and euthymic (E, n=66), depressed (D, n=43), or hypomanic/mixed (HM, n=13) patients with bipolar disorder (BD) were assessed with neuropsychological tests. These were from eight domains consistent with previous literature; auditory memory, visual memory, processing speed with interference resolution, verbal fluency and processing speed, conceptual reasoning and set-shifting, inhibitory control, emotion processing, and fine motor dexterity. RESULTS Of the eight factor scores, the HC group outperformed the E group in three (Processing Speed with Interference Resolution, Visual Memory, Fine Motor Dexterity), the D group in seven (all except Inhibitory Control), and the HM group in four (Inhibitory Control, Processing Speed with Interference Resolution, Fine Motor Dexterity, and Auditory Memory). LIMITATIONS The HM group was relatively small, thus effects of this phase of illness may have been underestimated. Effects of medication could not be fully controlled without a randomized, double-blind, placebo-controlled study. CONCLUSIONS Use of the factor scores can assist in determining ICPs for BD and related disorders, and may provide more specific targets for development of new treatments. We highlight strong ICPs (Processing Speed with Interference Resolution, Visual Memory, Fine Motor Dexterity) for further study, consistent with the existing literature.
منابع مشابه
دشواریهای تشخیص اختلال دوقطبی در کودکان: از چارچوب تشخیصی رسمی تا معیارهای تشخیصی آشفتگی شدید در تنظیم خلق
AbstractObjectives: Defining bipolar disorder in children is a topic of multiple debates. DSM-IV criteria can not cover all clinical phenotypes. This paper represents a literature review on this topic. Method: In a review study, data were collected through searching in relevant databases and assessing available texts. Results: Developmental processes may change clinical presentation of bipolar ...
متن کاملThe Comparison of Sustained Attention and Cognitive Deficits in Patients with Schizophrenia and Bipolar Disorder Type II
Objective: The purpose of this study was to compare the sustained attention and cognitive deficits in patients with schizophrenia and bipolar disorder type II. Methods: The research method was causal-comparative (case-control) type. Statistical population was all the patients with bipolar disorder type II and schizophrenia at Isar and Fatemi hospitals in 2015 i...
متن کاملEfficacy of Mindfulness Based on Cognitive Therapy on Impulsivity and Self- Inhibition in Patients with Bipolar Disorder under Medical Treatment
Introduction: Bipolar disorder is combined with chronic symptoms that have effect on cognitive abilities and executive functions. The purpose of present study was to investigate efficacy of mindfulness based cognitive therapy (MBCT) on impulsivity and self-inhibition in the patients with bipolar disorder under medical treatment. Methods: This study was quasi-experimental, pretest-posttest desi...
متن کاملDevelopment and Validation of Cognitive Behavioral Therapy Package Based on Detachment of Emotion and Goal for Adjunctive Psychotherapy of Individuals with Bipolar Disorder: A Descriptive Study
Background and Objectives: Bipolar disorder has a lot of cost for treatment system. Adjunctive psychotherapies are used in treatment of bipolar disorder for reducing signs, preventing recurrence and increasing drug adherence. The aim of current research was developing and validating cognitive behavioral therapy based on detachment of emotion and goal for bipolar disorder. Materials and Methods...
متن کاملThe Comparison of Sustained Attention and Cognitive Deficits in Patients with Schizophrenia and Bipolar Disorder Type II
Objective: The purpose of this study was to compare the sustained attention and cognitive deficits in patients with schizophrenia and bipolar disorder type II. Methods: The research method was causal-comparative (case-control) type. Statistical population was all the patients with bipolar disorder type II and schizophrenia at Isar and Fatemi hospitals in 2015 i...
متن کاملDifferences and Similarities in Attentional Bias between Patients with Bipolar II Disorder and Borderline Personality Disorder
Background and purpose: The boundary between bipolar disorder and borderline personality disorder has always been a matter of debate. Despite the importance of this issue, only a few studies have directly compared these two groups. The main purpose of this study was to compare the cognitive profile of patients with bipolar disorder and borderline personality disorder in terms of attentional bia...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of affective disorders
دوره 122 3 شماره
صفحات -
تاریخ انتشار 2010